Dr David Humes (Diverticular disease)

2016 Bowel & Cancer Research/Guts UK Diverticular Research Development Grant

Dr David Humes - 2016 Bowel & Cancer Research/Guts UK Diverticular Research Development Grant
Dr David Humes – 2016 Bowel & Cancer Research/Guts UK Diverticular Research Development Grant

Institution: University of Nottingham

Title: What are the short and long term outcomes of minimally invasive approaches (e.g., percutaenous radiological drainage, laparoscopic washout and drainage) to managing complicated diverticulitis?

Project Start Date: 1 December 2016

Completion Date: 30 November 2018

Complications of diverticular disease include the formation of abscesses (pockets of pus) and holes in the bowel called perforation. These conditions account for approximately 5000 emergency admissions per year to hospital. These complications often require surgery to treat them which is associated with a high risk of death and complications. There has therefore been interest in using less invasive methods such as key-hole surgery and drainage using image guided techniques to reduce the risk of complications. Currently there are no studies that report on the short and long term results of these techniques and no contemporary studies that report on how frequently these complications arise.

Professor Joe West is a Clinical Epidemiologist and gastroenterologist at the University of Nottingham who has previously published studies on the occurrence of and risk factors for perforated diverticular disease. He is an expert in using large linked health care data to study these conditions. Dr Colin Crooks is a Clinical Epidemiologist and Gastroenterology Trainee who has extensive experience in using the necessary complex statistical methodology in gastrointestinal conditions.

Using large databases of electronic health records we intend to identify patients with these complications of diverticular disease and report how frequently they occur, how often people die following them and from what causes. We will also report what the outcomes from these minimally invasive techniques are in terms of the need for further surgical intervention, stoma formation and re-admission to hospital. The work will be completed over a year period from November 2016.

The potential benefit to patients will be that we will be able to inform patients of the outcomes of these procedures which will aid in their decision making when being offered these treatments. This information will inform the consent process. This work will also improve our understanding of how frequently these conditions occur and what the associated risk of death and complications following them are.

This grant will allow us to provide much needed information to clinicians and patients on how frequently the complications of diverticular disease occur and what the consequences of these are. It will also provide information on the outcomes of current treatments used to treat these complications which better inform patients and clinicians when making decisions regarding which treatments to use.

Dr David Humes